Diabetes - Pumpkin Extract showed some promise for Insulin Reduction or Replacement by Mark Barone

Researchers from East China Normal University discovered that diabetic rats fed pumpkin extract improved plasma insulin and insulin-positive (beta) cells to almost normal levels. The study by Lisa Richards in Chemistry & Industry reported on this study.

"Pumpkin extract is potentially a very good product for pre-diabetic persons, as well as those who have already developed diabetes," said lead researcher, Tao Xia, from the East China Normal University.

The diabetic rats that received the pumpkin extract achieved plasma insulin levels that were only 5% less than normal rats. The diabetic mice also benefited with improved insulin-positive (beta) cells, with only 8% fewer than normal rats.

The key ingredients it thought to be antioxidants and D-chiroinositol which helps mediates insulin activity. By improving the insulin levels, blood sugar levels were lowered. This in turn reduces the amount of oxidative oxygen species that further damage beta-cell membranes. This prevents further damage, which allows for some regeneration. The rats never did recoup full beta-cell capabilities because they were damaged beyond repair.

At this time studies have only been conducted on rats, and it would be too soon to say if humans would experience the same benefits.

The rats in this study had type 1 diabetes. The researchers believe that type 2 diabetes would also benefit from the pumpkin extract.

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